Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

732
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
732
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

986
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
986

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is the future of cardiac repair cell-free?

European heart journal·2026
Same author

A causal 'lnc' between exercise and ageing in the cardiac vasculature.

European heart journal·2026
Same author

The dark genome in cardiovascular medicine.

European heart journal·2026
Same author

Lymphedema therapy in head & neck cancer with carotid stenosis: a systematic review and care pathway.

Oral oncology·2026
Same author

Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction.

PLoS biology·2026
Same author

Vein graft failure: Pathophysiology, detection, prevention and emerging therapeutic strategies.

Pharmacological reviews·2026

Related Experiment Video

Updated: Jul 3, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.5K

Clonal Expansion in Cardiovascular Pathology.

Alexander Lin1,2, Mairi Brittan3, Andrew H Baker3,4

  • 1Atherosclerosis and Vascular Remodeling Group, Heart Research Institute, Sydney, New South Wales, Australia.

JACC. Basic to Translational Science
|February 16, 2024
PubMed
Summary

Clonal expansion of vascular cells is observed across many cardiovascular diseases, suggesting stem-like cells drive disease progression. Understanding and targeting these clones may offer novel therapeutic strategies for cardiovascular conditions.

Keywords:
cardiovascular diseasesclonal expansionendothelial cellsmacrophagesvascular smooth muscle cells

More Related Videos

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

12.2K
Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
05:38

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells

Published on: February 12, 2021

4.1K

Related Experiment Videos

Last Updated: Jul 3, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

12.5K
Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
08:14

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models

Published on: October 3, 2019

12.2K
Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
05:38

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells

Published on: February 12, 2021

4.1K

Area of Science:

  • Cardiovascular Biology
  • Cellular Clonality
  • Disease Pathogenesis

Background:

  • Clonal expansion, the Darwinian proliferation and selection of advantageous cell clones, is increasingly recognized in cardiovascular diseases.
  • While cell clonality in the cardiovascular system is better understood, the mechanisms driving clonal selection remain largely unknown.
  • A common pattern of clonal expansion involving smooth muscle cells, endothelial cells, and macrophages is observed across diverse cardiovascular pathologies.

Purpose of the Study:

  • To comprehensively review current knowledge on clonal expansion in the cardiovascular field.
  • To explore the potential existence and role of stem-like vascular cells in disease.
  • To evaluate the clinical implications of targeting clonal cells for therapeutic interventions.

Main Methods:

  • Review of existing literature on clonal expansion in cardiovascular diseases.
  • Comparative analysis of clonal cell behavior in atherosclerosis, pulmonary hypertension, aneurysm, and other conditions.
  • Discussion of potential therapeutic strategies targeting clonal vascular cells.

Main Results:

  • Clonal expansion of vascular cells is a recurring theme in various cardiovascular diseases, regardless of microenvironment.
  • Evidence suggests the presence of disease-primed, stem-like vascular cells contributing to clonal expansion.
  • Phenotypic changes in subsequent clones can result in either protective or detrimental roles.

Conclusions:

  • Investigating clone-forming vascular cells offers insights into disease mechanisms.
  • Harnessing the inherent clonal nature of vascular cells presents potential therapeutic avenues.
  • Targeting specific clonal cells may lead to unique treatment options for cardiovascular diseases.