Alternative in-vivo models of mucormycosis
Jakob Scheler1, Ulrike Binder1
1Department of Hygiene, Microbiology and Public Health, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Tirol, Austria.
Abstract:
Mucormycosis is still regarded a rare fungal infection, but the high incidences of COVID-associated cases in India and other countries have shown its potential threat to large patient cohorts. In addition, infections by these fast-growing fungi are often fatal and cause disfigurement, badly affecting patients' lives. In advancing our understanding of pathogenicity factors involved in this disease, to enhance the diagnostic toolset and to evaluate novel treatment regimes, animal models are indispensable. As ethical and practical considerations typically favor the use of alternative model systems, this review provides an overview of alternative animal models employed for mucormycosis and discusses advantages and limitations of the respective model.
Insights
Mucormycosis, a dangerous fungal infection, poses a significant threat, especially with COVID-19. This review examines alternative animal models for studying mucormycosis, aiding in diagnostics and treatments.
Area of Science:
- Mycology
- Infectious Diseases
- Animal Modeling
Background:
- Mucormycosis is a rare but severe fungal infection.
- COVID-19 has increased mucormycosis incidence, highlighting its threat.
- Infections are often fatal and cause disfigurement.
Purpose of the Study:
- To review alternative animal models for mucormycosis research.
- To discuss the advantages and limitations of each model.
- To aid in developing better diagnostics and treatments.
Main Methods:
- Literature review of alternative animal models for mucormycosis.
- Analysis of model systems based on ethical and practical considerations.
Main Results:
- Identified various alternative animal models for mucormycosis.
- Detailed the pros and cons of each model system.
Conclusions:
- Alternative animal models are crucial for understanding mucormycosis.
- Model selection impacts research on pathogenicity, diagnostics, and therapeutics.
