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Development and Characterization of Sulfasalazine Cubosomes for Potential Transdermal Drug Delivery
Mekha Mathew1, Anasuya Patil1, Hemanth G1
1Department of Pharmaceutics, KLE College of Pharmacy, Rajajinagar, Bengaluru, India.
Pharmaceutical Nanotechnology
|February 16, 2024
Summary
Transdermal sulfasalazine-loaded cubosomes offer a promising localized treatment for rheumatoid arthritis, improving drug delivery and efficacy compared to oral methods.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Rheumatoid arthritis is a progressive autoimmune disease affecting the synovial membrane, causing joint pain and swelling.
- Sulfasalazine, a BCS Class IV drug, exhibits poor solubility and permeability, limiting oral therapeutic efficacy.
- Cubosomes are explored as a transdermal drug delivery system to enhance localized drug effect and overcome sulfasalazine's limitations.
Purpose of the Study:
- To develop and evaluate transdermal sulfasalazine-loaded cubosomes for localized rheumatoid arthritis treatment.
- To improve upon the limitations of oral sulfasalazine administration through a novel transdermal approach.
Main Methods:
- Sulfasalazine-loaded cubosomes were fabricated using a top-down method with glyceryl monooleate (GMO) and Poloxamer 407.
- A 3^2 full factorial design was employed to optimize lipid and surfactant concentrations.
- Formulations underwent comprehensive characterization, including particle size, zeta potential, entrapment efficiency, FTIR, SEM, in-vitro release, and ex-vivo permeation studies.
Main Results:
- Cubosomes exhibited particle sizes ranging from 65-129 nm with negative zeta potentials (-18.8 to -24.8 mV).
- Entrapment efficiency was high, between 87% and 95%.
- The optimized formulation demonstrated controlled in-vitro drug release over 12 hours, with superior ex-vivo permeation and deposition compared to sulfasalazine suspension.
Conclusions:
- Transdermal delivery of sulfasalazine-loaded cubosomes presents a viable strategy for managing rheumatoid arthritis.
- This approach holds potential for localized therapeutic effects and improved patient outcomes.
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