Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Tumour budding, a promising cancer prognostic factor, indicates worse survival in esophageal, gastric, pancreatic, and biliary tract cancers. Standardized criteria are needed for its clinical use.
Area Of Science
- Oncology
- Pathology
- Biostatistics
Background
- Tumour budding is a potential prognostic marker in cancer.
- Its clinical application is limited by a lack of large, validated studies and standardized criteria.
- This meta-analysis focuses on noncolorectal gastrointestinal and pancreatobiliary tract cancers.
Approach
- A comprehensive literature review was performed using PubMed, Embase, and Web of Science up to February 20, 2023.
- Pooled odds ratios and hazard ratios were calculated to assess the association between tumour budding and clinicopathological features, as well as overall survival.
- Study quality was evaluated using the Newcastle-Ottawa Scale, and heterogeneity and publication bias were analyzed.
Key Points
- High-grade tumour budding was associated with significantly worse overall survival in esophageal squamous cell carcinoma, gastric adenocarcinoma, pancreatic ductal adenocarcinoma, and biliary tract adenocarcinoma.
- Tumour budding consistently correlated with adverse clinicopathological features, including lymph node metastasis, lymphovascular invasion, and distant metastasis.
- High heterogeneity was observed across the included studies.
Conclusions
- Tumour budding is a valuable prognostic marker in various gastrointestinal and pancreatobiliary tract cancers.
- Standardized criteria specific to organ types are essential to improve the clinical utility of tumour budding assessment.
- Further research with standardized methodologies is warranted to solidify its role in cancer prognosis.
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