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Updated: Jul 3, 2025
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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
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Huntington's disease prevalence in Asia: a systematic review and meta-analysis
Basavaraja Papanna1, Carlo Lazzari2, Marco Rabottini3
1Department of General Adult Psychiatry, Essex Partnership University Foundation Trust, Essex, United Kingdom.
Rivista Di Psichiatria
|February 16, 2024
Summary
Huntington's disease (HD) affects the Asian population less than the Western population, with the lowest prevalence in China. This difference may be due to social stigma, lack of testing, and genetic factors in Asian populations.
Area of Science:
- Neurology
- Epidemiology
- Genetics
Background:
- Epidemiological studies indicate lower Huntington's disease (HD) prevalence in Asian populations compared to Western populations.
- This systematic review aims to compare the impact of HD on the Asian population.
Conclusions:
- Huntington's disease impacts the Asian population to a lesser extent than the European population.
- Potential reasons for lower prevalence include social stigma, fear of marriage impact, and limited access to genetic/neurological testing.
- Genetic factors, such as specific CAG repeat subgroups and haplogroup C, may contribute to lower HD predisposition in Asians compared to Caucasians.
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