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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Jul 3, 2025

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

Engineered Bio-Based Hydrogels for Cancer Immunotherapy.

Yuxuan Peng^1,2, Shuang Liang^1,2, Qian-Fang Meng³

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Advanced Materials (Deerfield Beach, Fla.)

|February 16, 2024

Summary

This summary is machine-generated.

Bio-based hydrogels offer a promising platform for cancer immunotherapy, enhancing immune response and reducing side effects. This review explores their applications and potential for clinical translation.

Keywords:

bio‐based hydrogels cancer treatment immune activation immunotherapy localized administration

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Area of Science:

Biomedical Engineering
Materials Science
Immunology

Background:

Immunotherapy is revolutionizing cancer treatment but faces challenges like limited efficacy and side effects, particularly in solid tumors.
Hydrogels are versatile biomaterials for controlled drug and cell delivery.
Immunomodulatory hydrogels can enhance anti-cancer immune responses and minimize systemic toxicity via localized delivery.

Purpose of the Study:

To review recent advances in bio-based hydrogels for cancer immunotherapy.
To highlight synergistic combinatorial approaches utilizing these hydrogels.
To guide the rational design of hydrogels for improved cancer immunotherapy outcomes.

Main Methods:

Review of recent scientific literature on bio-based hydrogels in cancer immunotherapy.
Analysis of applications and synergistic strategies.
Discussion of hydrogel properties, including biocompatibility and controlled release.

Main Results:

Bio-based hydrogels demonstrate significant potential in cancer immunotherapy due to their biocompatibility and tunable properties.
Encapsulation and localized delivery within hydrogels can enhance therapeutic efficacy and reduce immune-related side effects.
Synergistic combinations of hydrogels with other therapeutic modalities show promise for improved treatment outcomes.

Conclusions:

Bio-based hydrogels are a promising platform for advancing cancer immunotherapy.
Further research and rational design are crucial for clinical translation.
These materials offer a pathway to more effective and safer cancer treatments.