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Updated: Jul 3, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
A chiral metal-organic framework/cyclodextrin sensing interface for the chiral discrimination of tryptophan
Haowei Huang1, Junyao Li1, Wenrong Cai1
1Jiangsu Key Laboratory of Advanced Materials and Technology, Changzhou University, Changzhou 213164, China. yzkongyong@cczu.edu.cn.
Abstract:
A chiral metal-organic framework (CMOF) was synthesized by introducing L-histidine (L-His) to zeolitic imidazolate framework-8 (ZIF-8) and then grafting with carboxymethyl-β-cyclodextrin (CM-β-CD). Compared with L-His-ZIF-8, the CM-β-CD-functionalized L-His-ZIF-8 (L-His-ZIF-8-CD) showed significantly enhanced discrimination ability for the tryptophan (Trp) enantiomers owing to the inherent chirality of CM-β-CD. The specificity of the chiral interface was also studied, and the results indicated that the discrimination ability for Trp enantiomers is significantly stronger than that for the enantiomers of cysteine (Cys) and tyrosine (Tyr), which might be due to the better matching between the indole ring of Trp and the chiral cavity of CM-β-CD.
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