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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Triplet Energy Transfer Mechanism in Copper Photocatalytic N- and O-Methylation
Martijn Hoving1, Jacob-Jan Haaksma1, Anne Stoppel1
1Stratingh Institute for Chemistry, University of Groningen, 9747 AG, Groningen, The Netherlands.
Abstract:
Methylation reactions are chemically simple but challenging to perform under mild and non-toxic conditions. A photochemical energy transfer strategy was merged with copper catalysis to enable fast reaction times of minutes and broad applicability to N-heterocycles, (hetero-)aromatic carboxylic acids, and drug-like molecules in high yields and good functional group tolerance. Detailed mechanistic investigations, using kinetic analysis, aprotic MS, UV/Vis, and luminescence quenching experiments revealed a triplet-triplet energy transfer mechanism between hypervalent iodine(III) reagents and readily available photosensitizers.
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