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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
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Corticosteroids and mania: A systematic review.

Mathias De Bock1, Pascal Sienaert2

  • 1University Psychiatric Center KU Leuven, KU Leuven, Kortenberg, Belgium.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
|February 16, 2024
PubMed
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Corticosteroid use can commonly cause mania, especially at prednisone equivalent doses over 40mg. Clinicians should monitor patients for psychiatric side effects and consider dose adjustments or psychotropic medications.

Keywords:
Corticosteroidsmaniareview

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Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Corticosteroids are frequently prescribed medications with potential psychiatric side effects.
  • Emerging evidence links corticosteroid use to the development of mania.

Approach:

  • A systematic review and meta-analysis was conducted.
  • Searched major electronic databases for studies up to January 12, 2023.
  • Included studies investigating corticosteroid use and mania in adult patients.

Key Points:

  • Mania is a recognized adverse psychiatric effect of corticosteroid therapy.
  • Higher doses, specifically prednisone equivalent doses above 40mg, are associated with increased risk.
  • Potential risk factors and dose-response relationships were explored.

Conclusions:

  • Mania is a common side effect of corticosteroid use.
  • Clinical vigilance, dose management, and psychotropic interventions are crucial for managing corticosteroid-induced mania.