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LCN2 and ELANE overexpression induces sepsis
Tao Wang1,2, Jian-Ge Han2, Wei Dong2
1Department of Anesthesiology, Tianjin University Chest Hospital, Jinnan District, Tianjin, China.
Medicine
|February 16, 2024
Summary
Lipocalin-2 (LCN2) and elastase, neutrophil expressed (ELANE) are highly expressed in sepsis patients. These genes may serve as key molecular targets for sepsis diagnosis and treatment.
Area of Science:
- Genomics and Bioinformatics
- Immunology and Infectious Diseases
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- The specific roles of Lipocalin-2 (LCN2) and elastase, neutrophil expressed (ELANE) in sepsis pathogenesis require further elucidation.
Purpose of the Study:
- To investigate the relationship between LCN2, ELANE, and sepsis.
- To identify potential molecular targets for sepsis management.
Main Methods:
- Analysis of sepsis datasets (GSE137340, GSE154918) using bioinformatics approaches.
- Differential gene expression analysis, Weighted Gene Co-expression Network Analysis (WGCNA), and Protein-Protein Interaction (PPI) network construction.
- Functional enrichment (GO, KEGG) and immune infiltration analyses were performed.
Main Results:
- 328 differentially expressed genes (DEGs) were identified, enriched in immune and inflammatory pathways.
- The PPI network highlighted MPO, ELANE, CTSG, and LCN2 as core genes.
- Core genes, particularly LCN2 and ELANE, showed high expression in sepsis samples and were linked to sepsis-related conditions.
Conclusions:
- LCN2 and ELANE are significantly upregulated in sepsis.
- These genes represent promising molecular targets for sepsis diagnosis and therapeutic intervention.
