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Updated: Jul 2, 2025
A Tissue Culture Model of Estrogen-producing Primary Bovine Granulosa Cells
Published on: September 6, 2018
Adult-type granulosa cell tumor associated with elevated luteinizing hormone: Two rare case reports
Yujing Wang1, Na Wang1, Xuejiao Zhang1
1Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.
Introduction:
Adult-type granulosa cell tumors (AGCTs), which account for 2% to 5% of all malignant ovarian tumors, are rare sex cord-stromal tumors that usually secrete excess estrogens, but they can also secrete androgens.
Patient Concerns:
We report 2 patients of childbearing age with AGCT who presented with the complaint of abnormal menstruation and elevated luteinizing hormone (LH), and mildly elevated testosterone.
Diagnosis:
The ovarian tumors had hormonal activity.
Interventions:
The 2 patients underwent laparoscopic left adnexectomy. The second patient underwent 4 cycles of chemotherapy with paclitaxel and carboplatin as adjuvant treatments.
Outcomes:
Their postoperative pathology confirmed AGCTs. Also, their menstrual cycle returned to normal, with normal serum LH and testosterone levels. There was no sign of recurrence.
Conclusion:
The cases suggest that elevated serum LH levels may be a sign of unknown tumors in cases of oligomenorrhea or secondary amenorrhea. It is useful to evaluate the serum levels of inhibin B and anti-Müllerian hormone to improve the early recognition of ovarian granulosa cell tumors.
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