Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

92
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
92
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined technology-enhanced home exercise and acupressure (TEHEplus) program on symptoms among cancer patients receiving immunotherapy: a feasibility study.

BMC cancer·2025
Same author

The Johns Hopkins Hope at Hopkins Clinic: supporting the comprehensive needs of individuals with metastatic breast cancer.

Breast cancer research and treatment·2025
Same author

Telemedicine and Virtual Interventions in Cancer Rehabilitation: Practical Application, Complications and Future Potentials.

Current oncology reports·2024
Same author

Prospective phase II trial of preoperative hypofractionated proton therapy for extremity and truncal soft tissue sarcoma: the PRONTO study rationale and design.

Radiation oncology (London, England)·2024
Same author

Pragmatic Approaches to Scalable Prehabilitation.

European urology focus·2024
Same author

Advocacy in Cancer Rehabilitation-A Beginner's Guide to Effecting Change.

American journal of physical medicine & rehabilitation·2024

Related Experiment Video

Updated: Jul 2, 2025

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K

Fractured Knowledge: Making Sense of Exercise in Patients With Bone Metastases.

Jessica Engle1, Genevieve Marshall, Todd Lefkowitz

  • 1From the Johns Hopkins School of Medicine, Baltimore, Maryland (JE); Sloan Kettering Memorial Hospital, New York, New York (GM); and Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York (TL, SM).

American Journal of Physical Medicine & Rehabilitation
|February 16, 2024
PubMed
Summary

Individuals with bone metastases can safely engage in supervised exercise, contrary to traditional beliefs. Exercise improves quality of life by reducing fatigue and enhancing physical function in cancer patients.

More Related Videos

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

4.8K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.7K

Related Experiment Videos

Last Updated: Jul 2, 2025

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

42.1K
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
06:32

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

4.8K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.7K

Area of Science:

  • Oncology
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Traditional recommendations advised cancer patients with bone metastases to limit physical activity due to perceived skeletal risks.
  • Evidence suggests that adverse skeletal events during supervised exercise in this population are rare.
  • Inactivity poses significant health risks, contrasting with the potential benefits of exercise.

Approach:

  • This review examines the existing literature on exercise interventions for individuals with metastatic bone disease.
  • It focuses on assessing the safety and feasibility of incorporating physical activity into cancer care.
  • The review considers the role of cancer rehabilitation physicians in managing exercise risks and benefits.

Key Points:

  • Supervised exercise programs can be safe and beneficial for patients with cancer-related bone metastases.
  • Exercise interventions are associated with improved mental well-being, reduced fatigue, and enhanced physical function.
  • The benefits of exercise for quality of life in cancer survivors with bone metastases are significant.

Conclusions:

  • Current evidence supports the integration of exercise and rehabilitation therapies for individuals with metastatic bone disease.
  • Cancer rehabilitation physicians play a crucial role in risk assessment and management for these patients.
  • Well-designed exercise regimens are feasible and recommended for improving outcomes in cancer patients with bone metastases.