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Updated: Jul 2, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Driven Deoxygenative Heteroarylation of Alcohols with Heteroaryl Sulfones
Yanjiao Xiong1, Qi Zhang1, Jun Zhang1
1Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. China.
Abstract:
The visible-light-promoted deoxygenative radical heteroarylation of alcohols was achieved in the absence of any external photosensitizers. The processes occur through the generation of xanthate salts from alcohols, followed by SET and fragmentation, delivering alkyl radicals to react with heteroaryl sulfones. This method is amenable for a wide range of alcohols with good functional group tolerance, providing a practical strategy for the alkylation of benzo-heteroaromatics. Mechanism studies indicate that direct visible-light excitation of xanthate anions and subsequent SET initiate the reactions.
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