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Related Experiment Video

Updated: Jul 2, 2025

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Long-term training alters response dynamics in the aging auditory cortex.

Jonah K Mittelstadt1, Kelson V Shilling-Scrivo2, Patrick O Kanold3

  • 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Biology, University of Maryland, College Park, MD 20742, USA.

Hearing Research
|February 16, 2024
PubMed
Summary
This summary is machine-generated.

Consistent auditory training in mice helps maintain youthful auditory cortex function in old age. This training preserved neural activity patterns, mitigating age-related auditory dysfunction.

Keywords:
Auditory cortexCortical plasticityNeuroplasticityResponseTraining

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Aging Research

Background:

  • Age-related auditory dysfunction, or presbycusis, is linked to changes in the auditory cortex (ACtx), including altered neural response dynamics and increased population correlations.
  • Cortical function is known to be adaptable and can be modified through training.

Purpose of the Study:

  • To investigate whether consistent engagement in auditory tasks can benefit auditory function in aged animals.
  • To determine if auditory training can preserve youthful neuronal activity patterns in the auditory cortex of aging mice.

Main Methods:

  • Adult mice were trained on a low-effort tone-detection task for at least six months.
  • Functional responses in the auditory cortex (ACtx) were examined in aged mice (approximately 18 months old) using in vivo 2-photon calcium imaging.
  • Sound-evoked responses of thousands of ACtx neurons were compared between trained old animals and passively exposed old animals.

Main Results:

  • Mice maintained stable performance on the tone-detection task into old age.
  • Trained old animals exhibited preserved aspects of youthful neuronal activity compared to passively exposed controls.
  • Preserved features included lower neural activity correlations, reduced neural excitability, and a higher proportion of suppressed responses in trained old animals.

Conclusions:

  • Consistent, low-effort auditory task training can ameliorate age-related functional declines in the auditory cortex.
  • Auditory training may help preserve key aspects of auditory function throughout the aging process.