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Updated: Jul 2, 2025
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Papillitis associated with IgLON5 autoimmunity: A novel clinical phenotype
Xiaoyang Li1, John J Chen2, Minjun Hur3
1Department of Neurology, Mayo Clinic, Rochester, USA.
Objectives:
To describe papillitis as a clinical phenotype of IgLON5 autoimmunity.
Methods:
We retrospectively reviewed patients with IgLON5 autoimmunity who had optic neuropathy, optic neuritis, or optic disc edema. Sera from patients with recurrent papillitis were tested for IgLON5 antibodies.
Results:
We found two elderly males presenting with papillitis in the presence of IgLON5 antibodies. CSF pleocytosis was present and partial vision improvement occurred in one patient despite immunotherapy. Sera from 18 patients with recurrent papillitis were negative for IgLON5 antibodies.
Conclusion:
Papillitis could be a manifestation of IgLON5 disease, with or without accompanying cognitive, sleep, and movement disorders.
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