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Association of bilateral oophorectomy with incidence of Parkinson's disease: A systematic review and meta-analysis
Abraish Ali1, Syeda Areeba Tabassum2, Zuhaa Rehman3
1Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Parkinsonism & Related Disorders
|February 16, 2024
Summary
Bilateral oophorectomy is linked to a higher risk of parkinsonism, but not Parkinson's disease itself. Further research is needed to clarify the relationship between this surgical procedure and neurodegenerative disorders.
Area of Science:
- Neurology
- Gynecology
- Epidemiology
Background:
- Conflicting evidence exists regarding the association between bilateral oophorectomy and Parkinson's disease (PD).
- This study aimed to clarify the relationship by analyzing large, powered observational studies.
Approach:
- A systematic literature search was conducted across three databases up to October 2022.
- Four observational studies were included, focusing on pre- and post-menopausal women undergoing bilateral oophorectomy.
- Risk Ratios (RR) with 95% Confidence Intervals (CI) were calculated and pooled using a random-effects model.
Key Points:
- Bilateral oophorectomy showed a significant association with parkinsonism (RR: 1.80, 95% CI: 1.29 to 2.52).
- No significant association was found between bilateral oophorectomy and Parkinson's disease (RR: 1.38, 95% CI: 0.76 to 2.49).
- Concomitant hysterectomy with bilateral oophorectomy increased Parkinson's risk (RR: 1.4, 95% CI: 1.13 to 1.74).
Conclusions:
- Bilateral oophorectomy is significantly associated with an increased incidence of parkinsonism.
- The relationship between oophorectomy and Parkinson's disease requires further investigation.
- Factors like age at surgery and post-menopausal hormonal use did not show significant associations with parkinsonism or Parkinson's disease.
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