Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

1.6K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.6K
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

2.8K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.

eLife·2026
Same author

Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.

bioRxiv : the preprint server for biology·2026
Same author

Healing of ischemic injury in the retina.

Science advances·2026
Same author

Retrograde control of sympathetic neuron-satellite glia interactions by target-derived NGF signaling.

Cell reports·2025
Same author

Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa.

Investigative ophthalmology & visual science·2025
Same author

Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa.

bioRxiv : the preprint server for biology·2025
Same journal

Transcending Genome-Wide Association Studies to Create Useful Multi-omic Views of Glaucoma.

Progress in retinal and eye research·2026
Same journal

Cutting-edge cross-linking biomaterials advancing ophthalmic therapeutics.

Progress in retinal and eye research·2026
Same journal

Scleral remodeling in myopia: mechanisms and therapeutic approaches.

Progress in retinal and eye research·2026
Same journal

Macular fibrosis secondary to neovascular age-related macular degeneration: from clinic to biology.

Progress in retinal and eye research·2026
Same journal

Stromal Transplantation and corneal-sparing techniques in ectatic diseases.

Progress in retinal and eye research·2026
Same journal

Diabetic retinal disease cure accelerator: Modernizing staging and endpoints.

Progress in retinal and eye research·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2025

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

2.5K

Modeling complex age-related eye disease.

Silke Becker1, Zia L'Ecuyer1, Bryan W Jones1

  • 1John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.

Progress in Retinal and Eye Research
|February 16, 2024
PubMed
Summary
This summary is machine-generated.

Mouse models for age-related eye diseases like AMD and glaucoma are valuable but have limitations. Alternative models like organoids and larger animals may offer better insights into disease progression and therapy testing.

Keywords:
Age-related diseaseAge-related macular degenerationDrusenEye diseaseGeographic atrophyGlaucomaMouse modelNon-human primate modelOptic nerve degenerationRabbit modelRetina

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.1K
Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

13.7K

Related Experiment Videos

Last Updated: Jul 2, 2025

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
06:16

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies

Published on: July 28, 2023

2.5K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.1K
Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

13.7K

Area of Science:

  • Ophthalmology
  • Genetics
  • Animal Models

Background:

  • Age-related macular degeneration (AMD) and glaucoma are complex eye diseases with high heritability but unknown contributing factors.
  • Genetic risk variants do not guarantee disease development, indicating the influence of environmental and lifestyle factors.
  • Current research utilizes various animal models to study disease mechanisms, but their efficacy is debated.

Purpose of the Study:

  • To review the utility and limitations of mouse models for age-related eye diseases.
  • To discuss alternative models for studying disease progression and testing therapies.
  • To highlight the challenges in recapitulating human disease in animal models.

Main Methods:

  • Review of existing literature on mouse models for AMD and glaucoma.
  • Analysis of anatomical, physiological, and genetic differences between mice and humans.
  • Discussion of alternative models including non-human primates, rabbits, retinal organoids, and human donor eyes.

Main Results:

  • Mouse models offer insights into the pathobiology of age-related eye diseases but have limitations.
  • Concerns exist regarding mouse models' ability to fully replicate human disease progression and vision loss.
  • Alternative models show promise but also have their own advantages and disadvantages.

Conclusions:

  • While mouse models are useful for initial research, their limitations necessitate exploring alternative models.
  • Larger animals, organoids, and human donor eyes may provide more accurate models for studying disease and testing therapies.
  • Further research is needed to determine the most effective models for advancing the understanding and treatment of age-related eye diseases.