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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Anatomy of the Intestines01:23

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

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Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
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Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Related Experiment Video

Updated: Jul 2, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

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Risk Factors for Infection in Neonates With Intestinal Failure.

Dana Wu1, Rhonda Van Oerle2, Andrea Martinez3

  • 1Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Journal of Pediatric Surgery
|February 16, 2024
PubMed
Summary

Neonates with intestinal failure often develop infections, with prematurity and complex gastroschisis as key risk factors. While infections impact growth, they did not significantly alter weight gain trajectories in this study.

Keywords:
InfectionIntestinal failureNeonates

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Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Infectious Diseases

Background:

  • Neonates with intestinal failure (IF) face significant infection risks from central venous access and surgery.
  • Infections in IF can lead to systemic inflammation, sepsis, and impaired growth.
  • Preventative strategies are crucial for managing IF-related infections.

Purpose of the Study:

  • Identify risk factors for infection in neonates with IF.
  • Assess the impact of infection on growth in this vulnerable population.
  • Inform the development of targeted preventative strategies.

Main Methods:

  • Retrospective comparative study of 86 neonates with IF (2018-2022).
  • Clinical data, intestinal pathology, nutrition, and growth were analyzed.
  • Infection groups (bloodstream, other, none) compared using Mann-Whitney and Kruskal-Wallis tests.

Main Results:

  • 59% of infants developed infection; 22% had bloodstream infections (BSI), 37% other infections (OI).
  • Infection was linked to lower gestational age, birthweight, and presence of a stoma.
  • All infants with complex gastroschisis contracted infections; growth (weight gain) was suboptimal but similar across groups.

Conclusions:

  • Infection is common in neonates with IF shortly after diagnosis.
  • Key risk factors include prematurity, complex gastroschisis, and stoma presence.
  • While growth is generally suboptimal, infection did not significantly impact weight gain trajectories.