Search research articles

Related Concept Videos

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Home
Cxcr4 Overexpression In Chronic Lymphocytic Leukemia Associates With Poorer Prognosis: A Prospective, Single-center, Observational Study.

Home
Cxcr4 Overexpression In Chronic Lymphocytic Leukemia Associates With Poorer Prognosis: A Prospective, Single-center, Observational Study.

Related Experiment Video

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center,

Xinran Xue¹, Zhihao Wen¹, Xin Zhang¹

¹Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.

Genes and Immunity

|February 17, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High C-X-C motif chemokine receptor 4 (CXCR4) expression in chronic lymphocytic leukemia (CLL) patients indicates a poorer prognosis and shorter progression-free survival. CXCR4 levels can be rapidly assessed by flow cytometry for prognostic insights.

More Related Videos

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

Published on: July 20, 2016

Related Experiment Videos

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells

Published on: July 20, 2016

Area of Science:

Hematology
Oncology
Immunology

Background:

Prognostic value of C-X-C motif chemokine receptor 4 (CXCR4) in chronic lymphocytic leukemia (CLL) remains controversial.
CXCR4 is implicated in the pathophysiology of various hematological malignancies.

Purpose of the Study:

To prospectively evaluate the role of CXCR4 in CLL pathophysiology.
To determine the prognostic significance of CXCR4 expression in CLL patients.

Main Methods:

Prospective observational study of 158 CLL patients.
CXCR4 expression on CLL cells measured by flow cytometry (FCM) at diagnosis.
RNASeq analysis on selected patient specimens.

Main Results:

Patients with high CXCR4 expression (CXCR4high) had significantly shorter progression-free survival (PFS) than those with low expression (CXCR4low).

CXCR4 overexpression (MFI > 3376) was an independent marker of poor PFS (P < 0.001).

RNASeq indicated CXCR4's role in CLL cell migration.

Conclusions:

CXCR4 expression levels on leukemia cells are rapidly detectable by FCM.
CXCR4 overexpression is significantly associated with a poorer prognosis in CLL patients.
CXCR4 serves as a potential prognostic biomarker in CLL.