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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Jun 30, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

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Published on: February 19, 2014

Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.

Jian Wu^1,2, Chaoye Wang³, Shuhui Sun^4,5,6

¹Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China.

|February 17, 2024

Summary

This summary is machine-generated.

Aging trabecular meshwork (TM) cells show mitochondrial dysfunction. Silencing APOE gene improves TM cell migration and function, offering potential glaucoma treatment insights.

Keywords:

aging macaque ocular outflow tissue single-cell transcriptomic atlas trabecular meshwork

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In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Area of Science:

Ophthalmology
Cell Biology
Genetics

Background:

Trabecular meshwork (TM) degradation is linked to age-related eye diseases like primary open-angle glaucoma.
The molecular mechanisms of TM aging remain largely unknown.

Purpose of the Study:

To investigate the molecular basis of TM aging using single-cell transcriptomics.
To identify key genes and pathways involved in TM dysfunction during aging.

Main Methods:

Established a dynamic single-cell transcriptomic landscape of aged macaque TM.
Classified TM cells into subtypes and clusters for in-depth analysis.
Investigated the role of APOE gene in TM aging and function.

Main Results:

Identified mitochondrial dysfunction as a key feature of TM aging.
Discovered APOE as a crucial differentially expressed gene in aging TM.
Showed that silencing APOE enhances cell migration, reduces apoptosis, and improves aqueous humor outflow.

Conclusions:

APOE gene plays a significant role in TM aging, affecting cell migration and extracellular matrix regulation.
Targeting APOE may offer a novel therapeutic strategy for glaucoma by restoring TM function and maintaining intraocular pressure.