Interaction between lncRNAs and RNA-binding proteins (RBPs) influences DNA damage response in cancer chemoresistance

Area of Science:

• Molecular Biology
• Cancer Research
• Genetics

Background:

• The DNA damage response (DDR) is vital for cellular repair after DNA damage, including chemotherapy-induced damage.
• Cancer chemoresistance, where tumor cells evade chemotherapy, is a major obstacle in effective cancer treatment.
• Long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) are emerging regulators in cancer biology and treatment response.

Purpose of the Study:

• To review the current understanding of interactions between lncRNAs and RBPs in the context of cancer chemotherapy.
• To elucidate the role of these interactions in modulating the DNA damage response (DDR) pathways.
• To highlight the therapeutic potential of targeting lncRNA-RBP complexes for overcoming chemoresistance.

Main Methods:

• Literature review of recent studies on lncRNAs, RBPs, DDR, and chemoresistance.
• Analysis of molecular mechanisms underlying lncRNA-RBP interactions.
• Synthesis of findings related to the impact on DDR signaling and cancer treatment outcomes.

Main Results:

• lncRNAs and RBPs interact to regulate gene expression post-transcriptionally, influencing DDR signaling.
• These interactions modulate genes critical for cancer chemoresistance.
• RBPs can also regulate lncRNA expression and function within DDR pathways.

Conclusions:

• The interplay between lncRNAs and RBPs significantly impacts cancer chemoresistance by affecting DDR.
• Targeting lncRNA-RBP interactions presents a promising strategy for developing novel therapeutic approaches.
• Further research into these molecular mechanisms is crucial for advancing cancer treatment.