Development and validation of survival nomograms in elder triple-negative invasive ductal breast carcinoma patients
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View abstract on PubMed
Summary
This summary is machine-generated.A new nomogram accurately predicts overall survival for elderly patients with Triple-negative invasive ductal breast carcinoma (TNIDC). This tool aids in individual risk assessment for nonmetastatic TNIDC.
Area Of Science
- Oncology
- Biostatistics
- Epidemiology
Background
- Triple-negative invasive ductal breast carcinoma (TNIDC) poses a significant challenge in elderly patients.
- Accurate prognostic tools are crucial for tailoring treatment strategies in this demographic.
Purpose Of The Study
- To develop and validate a nomogram for predicting overall survival in elderly patients with nonmetastatic TNIDC.
- To compare the predictive accuracy of the nomogram against the established TNM staging system.
Main Methods
- Utilized data from 12,165 elderly patients with nonmetastatic TNIDC from the SEER database (2010-2019).
- Employed stepwise Cox regression for variable selection and constructed nomograms using training and validation cohorts.
- Performed univariate, multivariate Cox analyses, and survival analysis for risk stratification.
Main Results
- Identified eleven predictive factors for nomogram construction, demonstrating superior discrimination (C-index 0.741/0.765) compared to TNM staging (C-index 0.708/0.725).
- The nomogram showed good prognostic accuracy and clinical applicability in both training and validation cohorts.
- Significant differences in overall survival were observed between high- and low-risk groups (p < 0.001).
Conclusions
- The developed nomogram serves as a reliable tool for individual prognostication in elderly patients with M0-stage TNIDC.
- The model's applicability may be limited to the American population studied.
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