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Persistent Gram-negative Bloodstream Infection Increases the Risk of Recurrent Bloodstream Infection With the Same

Paa Kwesi Ankrah1, Andrew Bock2, Felicia Ruffin1

  • 1Division of Infectious Disease, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 17, 2024
PubMed

Insights

Persistent gram-negative bloodstream infections (GN-BSI) are linked to higher rates of recurrence with the same bacteria. This suggests persistent GN-BSI may indicate a more complex infection requiring further investigation.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Gram-negative bloodstream infections (GN-BSI) are a significant cause of morbidity and mortality.
  • The clinical implications of persistent GN-BSI, defined as ongoing positive cultures, remain understudied.

Purpose of the Study:

  • To investigate the association between persistent GN-BSI and recurrent GN-BSI.
  • To determine if persistent GN-BSI is a marker for complicated infections.

Main Methods:

  • Retrospective analysis of 992 adult patients with GN-BSI.
  • Comparison of recurrence rates between patients with and without persistent GN-BSI.

Main Results:

  • Persistent GN-BSI was significantly associated with an increased risk of recurrent GN-BSI caused by the same bacterial species and strain (6% vs 2%; P = .04).

Conclusions:

  • Persistent GN-BSI may serve as a clinical marker for complicated gram-negative bloodstream infections.
  • Identifying persistent GN-BSI could aid in risk stratification and management of patients.
Keywords:
bloodstream infectiongram-negativerecurrentreinfectionrelapse

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