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Interactive calculator to estimate insulin sensitivity in type 1 diabetes
Andrzej S Januszewski1,2,3, Pawel Niedzwiecki4, Nirupa Sachithanandan2
1NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.
Journal of Diabetes Investigation
|February 17, 2024
Summary
Estimating insulin sensitivity (IS) in type 1 diabetes is crucial. While formulas vary, an online calculator helps consistently assess IS and complication risk, aiding research and clinical practice.
Area of Science:
- Endocrinology
- Metabolic Research
- Diabetes Management
Background:
- Insulin sensitivity (IS) is vital for metabolic health.
- Low IS correlates with increased complication risk in type 1 diabetes.
- The hyperinsulinemic-euglycemic clamp is the gold standard but is resource-intensive.
Purpose of the Study:
- To consolidate and compare various formulas for estimating IS in type 1 diabetes.
- To develop a user-friendly online calculator for IS assessment.
- To evaluate the consistency of IS interpretation across different formulas.
Main Methods:
- Consolidation of multiple IS estimation formulas.
- Development of an online calculator (bit.ly/estimated-GDR).
- Validation using clamp data from 104 adults with type 1 diabetes.
Main Results:
- Calculated IS values varied significantly between formulas (R² 0.005-0.87).
- Agreement in detecting low IS (<4.45 mg/kg/min) ranged from 49-93%.
- Agreement in detecting high IS (>6.50 mg/kg/min) ranged from 89-100%.
Conclusions:
- Despite variations in calculated IS, formula interpretation for low/high sensitivity remains consistent.
- The online calculator provides a reliable tool for individual and batch IS assessment.
- This tool facilitates research and clinical evaluation of insulin sensitivity in type 1 diabetes.
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