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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Skeletal Muscle Aging: Lessons From Teleosts.

Tuyen K Quach1, Megan F Taylor2, Peter D Currie2,3

  • 1Centre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|February 17, 2024
PubMed
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Aging causes sarcopenia, a loss of muscle mass and strength. Teleost fish models, like zebrafish, are valuable tools for studying sarcopenia mechanisms and developing new therapies.

Keywords:
Age-related pathologyFish modelsSarcopeniaSkeletal muscle

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Area of Science:

  • Gerontology and muscle physiology research.
  • Comparative biology and disease modeling.

Background:

  • Aging is the primary risk factor for numerous age-related diseases.
  • Sarcopenia, characterized by skeletal muscle mass and strength loss, significantly impacts health and mobility in aging populations.

Purpose of the Study:

  • To explore the utility of teleost fish as models for aging and sarcopenia research.
  • To review current understanding of sarcopenia mechanisms and therapeutic strategies in teleosts.

Main Methods:

  • Utilizing teleost species (zebrafish, African turquoise killifish, medaka) for aging and sarcopenia studies.
  • Leveraging advances in genomics, genome editing, and imaging in teleost models.
  • Investigating dietary, pharmacological, and genetic interventions.

Main Results:

  • Teleost models effectively recapitulate key hallmarks of sarcopenia observed in other species.
  • These models facilitate the study of underlying molecular and cellular mechanisms of age-related muscle decline.

Conclusions:

  • Teleost fish offer a powerful, cost-effective platform for aging and sarcopenia research.
  • Further research in teleosts can drive the development of novel therapeutic strategies to combat sarcopenia.