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In vitro efficacy testing of ivermectin against Tritrichomonas foetus trophozoites
Estefanía Sereno-Bruno1, Lumila Fuchs2, Jorge Oyhenart1
11Instituto de Ciencias de la Tierra y Ambientales de La Pampa (Consejo Nacional de Investigaciones Científicas y Técnicas - Facultad de Ciencias Naturales Universidad Nacional de La Pampa), Santa Rosa, La Pampa, Argentina.
Abstract:
There are no recommended drugs to treat cattle infected with the protozoan Tritrichomonas foetus (TF). Ivermectin, widely used in the treatment of intestinal parasites, was found effective against some protozoa growing in vitro. Here, its effectiveness against a TF line was investigated. Trophozoites were incubated in media with increasing concentrations of ivermectin and mortality was determined after 24 h. Ivermectin killed cells with a mean maximum effective concentration (EC50) of 2.47 μg mL-1. The effective concentration of ivermectin was rather high for a formulation suitable for systemic treatment. However, topical treatment of animals against TF could still be considered and tested.
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