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The therapeutic potential of targeting the CHD protein family in cancer

Min Zhang1, Kaiyuan Wu2, Weijie Zhang3

  • 1Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

Pharmacology & Therapeutics
|February 17, 2024
PubMed

Insights

Chromatin remodelers in the chromodomain helicase DNA-binding protein (CHD) family are key epigenetic regulators in cancer. Targeting these CHD proteins shows promise for novel antitumor therapies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic deregulation is a hallmark of cancer development.
  • Chromatin remodelers, particularly the chromodomain helicase DNA-binding protein (CHD) family, are frequently mutated in various cancers.
  • Dysregulation of CHD proteins contributes significantly to tumorigenesis.

Purpose of the Study:

  • To review the role of epigenetic modifications in cancer.
  • To highlight the function of chromodomain helicase DNA-binding protein (CHD) family members in cancer development.
  • To summarize current and emerging therapeutic strategies targeting CHD proteins.

Main Methods:

  • Literature review of epigenetic regulation in cancer.
  • Detailed analysis of chromodomain helicase DNA-binding protein (CHD) family functions.
  • Overview of preclinical and clinical trials targeting CHD proteins.

Main Results:

  • Chromodomain helicase DNA-binding protein (CHD) family members are frequently altered in cancer.
  • Targeting CHD proteins demonstrates potential for antitumor effects.
  • Emerging therapeutic strategies show early promise in preclinical settings.

Conclusions:

  • Epigenetic dysregulation by CHD proteins is critical in cancer.
  • Targeting CHD remodelers represents a viable strategy for cancer therapy.
  • Further research into CHD-targeted therapies could lead to effective treatments.
Keywords:
Cancer developmentChromatin remodelingEpigenetic regulationTherapeutic strategies

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