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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

57
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Related Experiment Video

Updated: Jul 2, 2025

Developing a Rat Model for Bipolar Disorder
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Published on: May 2, 2025

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Transcriptome profiling as a biological marker for bipolar disorder sub-phenotypes.

Joanna Pawlak1, Aleksandra Szczepankiewicz2, Maria Skibińska1

  • 1Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznań, Poland.

Advances in Medical Sciences
|February 18, 2024
PubMed
Summary

Bipolar disorder (BP) gene expression varies by clinical presentation. Psychotic symptoms in BP show the most distinct transcriptome profile, suggesting shared biological pathways with schizophrenia.

Keywords:
Bipolar affective disorderClinical sub-phenotypeTranscriptome profile

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Bipolar disorder (BP) significantly impacts patient and family quality of life.
  • Understanding genetic underpinnings of BP clinical variants is crucial for targeted treatments.

Purpose of the Study:

  • Investigate mRNA levels in BP patients to identify differentially expressed genes (DEGs).
  • Correlate gene expression patterns with specific clinical course variants of BP.

Main Methods:

  • Compared gene expression profiles in peripheral blood mononuclear cells from BP patients.
  • Analyzed RNA using microarray analysis across various clinical subgroups (BPI vs BPII, suicide attempts, psychosis, episode predominance, comorbidities).

Main Results:

  • DEGs were identified across all compared clinical characteristics.
  • Psychotic symptoms in BP revealed the highest number of DEGs (3223), indicating a distinct molecular signature.
  • Down-regulated genes were associated with cell migration, defense, and inflammatory responses.

Conclusions:

  • BP with psychotic symptoms exhibits a highly specific transcriptome profile.
  • Inflammatory and immune process genes are implicated in BP with psychotic features.
  • Findings suggest potential shared biological mechanisms between BP with psychosis and schizophrenia.