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Current State of Minitablet Product Design: A Review.

Saikishore Meruva¹, Aditya B Singaraju¹, Bhavani Prasad Vinjamuri²

¹University of Iowa, College of Pharmacy, Iowa City, IA 52242, USA.

Journal of Pharmaceutical Sciences

|February 18, 2024

Summary

Minitablets (MTs) are increasingly popular for personalized medicine and flexible dosing. Research shows MTs are highly acceptable for infants and elderly patients, overcoming swallowing difficulties.

Keywords:

Minitablets, Oral solid dosage forms, Pediatric, Geriatric, Minitablet applications, Tablet compresssion, Coating, Regulatory, Adherence, Acceptability

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Area of Science:

Pharmaceutical technology
Drug delivery systems
Patient-centric formulations

Background:

Minitablets (MTs) have seen a surge in research interest over the past two decades.
Advances in manufacturing and characterization have resolved earlier development challenges.
MTs offer advantages for personalized medicine, dose titration, and taste masking.

Purpose of the Study:

To review the current applications and advancements in minitablet technology.
To assess the acceptability and adherence of MTs in pediatric and geriatric populations.
To discuss manufacturing, characterization, packaging, and regulatory aspects of MTs.

Main Methods:

Literature review of publications in Scopus and PubMed.
Analysis of research on MT swallowability, acceptability, and palatability.
Examination of manufacturing processes, characterization techniques, and dispensing methods.

Main Results:

Minitablets are a viable and highly acceptable dosage form for pediatric and geriatric patients.
MTs address challenges in swallowing, taste, and flexible dosing.
Significant progress has been made in MT tooling, manufacturing, and characterization.

Conclusions:

Minitablets represent a significant advancement in drug delivery, particularly for specific patient populations.
The acceptability and manufacturing of MTs have improved, supporting their wider adoption.
Further research and regulatory considerations are key to maximizing MT potential.