Related Experiment Video

Updated: Jul 2, 2025

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Aberrant heartbeat-evoked potential in schizophrenia

Akihiro Koreki¹, Kamiyu Ogyu², Takahiro Miyazaki³

¹Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan; Department of Psychiatry, National Hospital Organization Chiba-Higashi Hospital, Chiba, Japan.

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|February 18, 2024

Summary

Patients with schizophrenia exhibit altered cortical interoceptive processing, specifically a positive shift in resting-state heartbeat-evoked potentials (HEPs) in frontal regions. This finding suggests a potential neural marker for schizophrenia, though not directly correlated with symptom severity.

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Self-disturbance is a core psychopathology in schizophrenia.
Abnormal interoception is implicated in self-disturbance, but cortical processing remains understudied.
Heartbeat-evoked potentials (HEPs) index cortical interoceptive processing.

Purpose of the Study:

To investigate resting-state HEPs in schizophrenia patients compared to healthy controls.
To explore the relationship between HEPs and schizophrenia psychopathology.
To determine if HEP alterations represent a trait marker in schizophrenia.

Main Methods:

Cross-sectional electroencephalogram (EEG) and electrocardiogram (ECG) study.
Compared resting-state HEPs in 61 schizophrenia patients and 31 healthy controls.
Analyzed HEPs in the 450–500 ms window post-R peak, adjusting for confounders.

Main Results:

Schizophrenia patients showed a significant positive HEP shift in frontal-central regions (p=0.008).
The most significant differences were observed in the right frontal area (p=0.002), peaking at F4 (p<0.001).
No correlation was found between HEP alterations and symptom severity.

Conclusions:

Altered cortical interoceptive processing, indicated by a positive late HEP shift, may be a trait abnormality in schizophrenia.
HEP alterations could provide insights into the neural basis of self-disturbance in schizophrenia.
Further research is needed to link HEPs to self-disturbance mechanisms.

Keywords:

Electroencephalogram HEP Interoception Schizophrenia Self-disturbances

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

Published on: April 26, 2024

Related Concept Videos

Disturbances in Heart Rhythm

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...

Mechanism of Cardiac Arrhythmias

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.

Electrophysiology of Normal Cardiac Rhythm

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Articles linked to this work by shared authors, journal, and citation graph.

The indirect association of subjective work performance with sleep quality and wellbeing among high-stress workers in Japan: a cross-sectional study.

Frontiers in public health·2026

Post-conclusion belief inflexibility bias assessed by a modified beads task in schizophrenia.

Schizophrenia research·2026

Community-based reference data and regression-based standard scores for interpreting Modified Tinkertoy Test performance in Japanese adults.

Applied neuropsychology. Adult·2026

Parenteral dextrose during refeeding is associated with electrolyte deficiencies in anorexia nervosa: a route-specific analysis of oral and parenteral nutrition.

Journal of eating disorders·2026

The heartbeat evoked potential and the prediction of functional seizure semiology.

Brain communications·2026

Stereotypical diagnostic bias for alcohol-induced ketoacidosis could lead to death: Normal blood sugar levels in SGLT2 blocker-induced severe diabetic ketoacidosis.

PCN reports : psychiatry and clinical neurosciences·2025

See all related articles