Undescribed sesquiterpenoids with NO production inhibitory activity from oleo-gum resin of Commiphora myrrha
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View abstract on PubMed
Summary
This summary is machine-generated.Nine new sesquiterpenoids from Commiphora myrrha were identified. Two compounds, commiphone A and commipholide D, demonstrated significant anti-inflammatory effects by inhibiting nitric oxide production and inflammatory cytokine gene expression.
Area Of Science
- Natural Product Chemistry
- Pharmacology
Background
- Commiphora myrrha oleo-gum resin is a traditional remedy with potential therapeutic properties.
- Sesquiterpenoids are a diverse class of natural products known for various biological activities.
Purpose Of The Study
- To isolate and characterize novel sesquiterpenoids from Commiphora myrrha.
- To evaluate the anti-inflammatory potential of isolated compounds.
Main Methods
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via 1D/2D NMR, HRESIMS, and computational methods (ECD, NMR).
- In vitro anti-inflammatory assays using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Main Results
- Nine new sesquiterpenoids were isolated: six cadinanes (1-6), two guianes (7-8), and one germacrane (9).
- Commiphone A (1) and commipholide D (7) showed significant inhibition of nitric oxide (NO) production (IC50 = 18.6 ± 2.0 μM and 37.5 ± 1.5 μM, respectively).
- Compounds 1 and 7 dose-dependently suppressed LPS-induced mRNA expression of inflammatory cytokines IL-1β, IL-6, and TNF-α.
Conclusions
- Commiphone A and commipholide D possess potent in vitro anti-inflammatory activity.
- These compounds represent promising leads for the development of new anti-inflammatory agents.
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