Prognostic Significance of Tumor-Infiltrating Lymphocytes and High-Risk Human Papillomavirus in Ocular Sebaceous Carcinoma: A Comprehensive Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.High-risk human papillomavirus (hrHPV) is not a prognostic factor for ocular sebaceous carcinoma (OSC). High tumor-infiltrating lymphocytes (TILs) and specific tumor origins independently predict better prognosis in OSC patients.
Area Of Science
- Oncology
- Pathology
- Ophthalmology
Background
- High-risk human papillomavirus (hrHPV) and tumor-infiltrating lymphocytes (TILs) are established prognostic markers in oropharyngeal squamous cell carcinoma.
- Their prognostic value in ocular sebaceous carcinoma (OSC), a rare condition, remains largely uninvestigated.
Purpose Of The Study
- To investigate the association between clinicopathologic features, biomarkers, and hrHPV infection in OSC.
- To determine the predictive potential of these factors for OSC prognosis.
Main Methods
- Analysis of clinicopathologic features from 81 OSC patients.
- Immunohistochemistry and DNA in situ hybridization on tissue microarrays to assess 17 biomarkers and hrHPV status.
- Progression-free survival analysis for 28 patients with over 5 years of follow-up.
Main Results
- hrHPV was detected in 38.3% of cases and associated with comedonecrosis, high Ki-67, lower E-cadherin, and loss of zinc finger protein 750.
- Loss of zinc finger protein 750 independently predicted hrHPV status.
- High TILs (≥10%) and specific sites of origin (gland of Zeis, meibomian gland) were independent prognostic factors for better progression-free survival.
- hrHPV status was not found to be an independent prognostic factor for OSC.
Conclusions
- Ocular sebaceous carcinoma prognosis is independent of hrHPV infection.
- High tumor-infiltrating lymphocytes and specific tumor origin sites are significant independent prognostic indicators for improved outcomes in OSC.
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