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Comprehensive Molecular Profiling And Clinicopathological Characteristics Of Gastric-type Mucinous Carcinoma Of The Uterine Cervix In Japanese Women.

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Comprehensive Molecular Profiling And Clinicopathological Characteristics Of Gastric-type Mucinous Carcinoma Of The Uterine Cervix In Japanese Women.

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Published on: September 18, 2020

Comprehensive Molecular Profiling and Clinicopathological Characteristics of Gastric-Type Mucinous Carcinoma of the

Hiroki Nasu¹, Shin Nishio¹, Jongmyung Park¹

¹Department of Obstetrics and Gynecology, Kurume University School of Medicine.

The Kurume Medical Journal

|February 18, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Gastric-type mucinous carcinoma (GAS) of the cervix, often diagnosed late, shows frequent TP53 and STK11 alterations. Molecular profiling reveals targetable genomic alterations, suggesting a role for precision medicine in treating this HPV-independent cancer.

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Area of Science:

Gynecologic Oncology
Molecular Pathology
Cancer Genomics

Background:

Gastric-type mucinous carcinoma (GAS) is the most common cervical adenocarcinoma independent of human papillomavirus (HPV).
GAS is typically diagnosed at advanced stages, presenting a poorer prognosis compared to usual-type endocervical adenocarcinoma.
Limited research exists on the molecular profile of GAS, though TP53 and STK11 genetic alterations are frequently reported.

Purpose of the Study:

To analyze the clinicopathological characteristics and molecular profile of cervical gastric-type mucinous carcinoma (GAS).
To identify common genomic alterations in GAS and assess their potential for targeted therapy.

Main Methods:

Analysis of fresh-frozen and formalin-fixed paraffin-embedded (FFPE) tissue specimens from 13 patients with GAS.

Next-generation sequencing (NGS) using Cancer Hotspot Panel v2 and FoundationOne companion diagnostic (F1CDx) assay.

Comprehensive analysis of clinicopathological data and genomic alterations in 42 genes.

Main Results:

Seventy-four genomic alterations were identified across 42 genes in the analyzed GAS specimens.
TP53, ATRX, CDKN2A, KRAS, APC, and STK11 were the most frequently altered genes, each found in at least three cases.
All six patients' FFPE samples analyzed with F1CDx assay exhibited targetable genomic alterations.

Conclusions:

Cervical gastric-type mucinous carcinoma (GAS) exhibits diverse genomic alterations, including frequent TP53 mutations, impacting signaling pathways and cell cycle regulation.
The presence of targetable alterations underscores the necessity of molecular profiling for developing effective precision medicine strategies against GAS.
Precision medicine approaches tailored to the specific molecular profile of GAS are crucial for improving patient outcomes.