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  11. Ki-67 Labeling Index Predicts Tumor Progression Patterns And Survival In Patients With Atypical Meningiomas Following Stereotactic Radiosurgery

Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery

Motoyuki Umekawa1, Yuki Shinya2,3, Hirotaka Hasegawa2

  • 1Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, 113-8655, Japan. umekawam-nsu@h.u-tokyo.ac.jp.

Journal of Neuro-Oncology
|February 18, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

High Ki-67 labeling index (LI) in atypical meningiomas predicts worse outcomes after stereotactic radiosurgery (SRS). This finding aids in managing patients and predicting tumor progression post-SRS.

Area of Science:

  • Neurosurgery
  • Oncology
  • Radiation Oncology

Background:

  • Atypical meningiomas are challenging tumors requiring precise treatment strategies.
  • Stereotactic radiosurgery (SRS) is a key modality for managing atypical meningiomas.
  • Predictive biomarkers are crucial for optimizing SRS outcomes.

Purpose of the Study:

  • To determine if Ki-67 labeling index (LI) correlates with clinical outcomes in patients with atypical meningiomas treated with SRS.
  • To assess the predictive value of Ki-67 LI for tumor control, progression, and survival after SRS.

Main Methods:

  • Retrospective analysis of 39 patients with atypical meningiomas undergoing SRS.
  • Categorization of Ki-67 LI into low (<5%), intermediate (5%-10%), and high (>10%) groups.
  • Evaluation of local tumor control rates (LCRs), progression-free rates (PFRs), disease-specific survival (DSS), and adverse radiation-induced events (AREs).
Keywords:
Atypical meningiomaKi-67 labeling indexRecurrence patternStereotactic radiosurgery

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Main Results:

  • Higher Ki-67 LI was significantly associated with lower 3-year LCRs (100% vs. 74% vs. 25%), PFRs (100% vs. 40% vs. 0%), and 5-year DSS rates (100% vs. 89% vs. 50%).
  • Multivariable analysis confirmed high LI as a predictor of lower LCR, PFR, and shorter DSS.
  • Adverse radiation-induced events were minimal (8%) across all groups.

Conclusions:

  • High Ki-67 LI is a significant predictor of tumor progression and tumor-related death following SRS for atypical meningiomas.
  • Ki-67 LI provides valuable prognostic information for guiding post-SRS management strategies.
  • This biomarker can help personalize treatment decisions for atypical meningioma patients.