The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding

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Yasmin Bay1, Mie Egeberg Jeppesen1, Karla Frydenvang1

  • 1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

FEBS Letters
|February 18, 2024
PubMed

Keywords:
BPAM344 binding modeGluK2 mutationsX‐ray crystallographycalcium‐sensitive fluorescence‐based assaydimer interfacepositive allosteric modulation

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