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Value of markers of systemic inflammation for the prediction of postoperative progression in patients with pancreatic neuroendocrine tumors

Value of markers of systemic inflammation for the prediction of postoperative progression in patients with pancreatic neuroendocrine tumors

Liu Yang ^1,2, Mengfei Fu ^1,2, Li Yu ³, Hanyu Wang ^1,2, Xiao Chen ^1,2, Hui Sun ^1,2

Liu Yang ^1,2, Mengfei Fu ^1,2, Li Yu ³

¹Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
²Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Department of Endocrinology, Union Hospital, Wuhan, China.
³Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

⁰Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Endocrinology +

|

February 19, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Systemic inflammation markers, particularly the lymphocyte to monocyte ratio (LMR), can predict tumor progression in patients with pancreatic neuroendocrine tumors (PNETs). Elevated NLR and PLR, and low LMR, correlate with poorer outcomes, with LMR being an independent predictor of progression-free survival.

Area Of Science

Oncology
Internal Medicine
Surgical Oncology

Background

Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms.
Non-invasive prognostic markers for PNETs are currently limited.
Systemic inflammatory responses may influence PNET progression.

Purpose Of The Study

To evaluate the prognostic value of preoperative systemic inflammatory markers in patients with PNETs.
To assess the correlation between inflammatory markers and tumor progression.
To identify predictors of progression-free survival in PNET patients.

Main Methods

Retrospective analysis of clinical data from 174 PNET patients undergoing surgery.
Evaluation of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and platelet to white blood cell ratio (PWR).
Utilized ROC analysis for optimal cutoff values and Cox proportional hazards models for survival analysis.

Main Results

Higher NLR and PLR, and lower LMR, were observed in patients with tumor progression.
Optimal cutoff values were identified for NLR (2.28), LMR (4.36), and PLR (120.91).
Low LMR and high NLR/PLR were associated with increased tumor progression and reduced progression-free survival (PFS).
Multivariate analysis confirmed LMR as an independent predictor of PFS (HR=3.128, P=0.031).

Conclusions

Systemic inflammatory markers, especially LMR, can predict postoperative progression in PNETs.
LMR emerges as a valuable non-invasive prognostic indicator for PNET patients.
These findings may aid in risk stratification and management of PNETs.

Keywords:

Lymphocyte to monocyte ratio biomarker markers of systemic inflammation pancreatic neuroendocrine tumors prognosis

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