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Inside anticancer therapy resistance and metastasis. Focus on CD36
Ioana M Lambrescu1,2, Gisela F Gaina1,2, Laura C Ceafalan1,2
1Cell Biology, Neurosciences, and Experimental Myology Laboratory, Victor Babeș Institute of Pathology, 050096 Bucharest, Romania.
Journal of Cancer
|February 19, 2024
Summary
CD36, a lipid receptor, is implicated in cancer drug resistance. Targeting CD36 offers new strategies for overcoming treatment resistance in various cancers, paving the way for personalized medicine.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Metabolism
Background:
- Drug resistance is a major challenge in cancer therapy.
- Lipid metabolism plays a crucial role in cancer progression and metastasis.
- CD36, a lipid transporter, is linked to poor prognosis in various cancers.
Purpose of the Study:
- To review the role of CD36 in resistance to cancer therapies.
- To explore CD36's involvement in both solid and hematological malignancies.
- To summarize emerging anti-CD36 therapies for personalized medicine.
Main Methods:
- Literature review of studies on CD36 and cancer drug resistance.
- Analysis of CD36's role in resistance to platinum-based and adjuvant therapies.
- Overview of current and developing anti-CD36 therapeutic strategies.
Main Results:
- CD36 expression is associated with resistance to various cancer treatments.
- CD36 contributes to drug resistance in both solid tumors and hematological cancers.
- Emerging therapies targeting CD36 show promise for overcoming treatment resistance.
Conclusions:
- CD36 is a critical factor in cancer treatment resistance.
- Targeting CD36 presents a promising avenue for novel cancer therapies.
- Further research into anti-CD36 strategies could lead to personalized cancer medicine.
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