Related Experiment Video
Updated: Jul 2, 2025

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
Published on: August 28, 2021
The Effects of Premedication With Three Different Doses of Intravenous Dexmedetomidine on Spinal Anesthesia: A
Chandraleela Sundararajan1, Ganesh Singaravelu2, Karthikeyan Selvaraj3
1Anesthesiology, Sri Venkateshwaraa Medical College Hospital, Puducherry, IND.
Background:
Intravenous dexmedetomidine is one of the commonly preferred techniques for sedation during any regional procedure. However, only a very few studies compared the impact of different bolus doses during spinal anesthesia, and none for our geographical area.
Materials And Methods:
A total of 60 patients were allocated into either of the three groups (group I, II, III) to receive intravenous dexmedetomidine 0.5, 0.75, and 1 mcg/kg, respectively. The primary outcome was to compare the duration of sensory and motor blockade and the secondary outcomes were the level of sedation, hemodynamic stability, duration of analgesia, and the side effects, if any.
Results:
Two-dermatome regression time and the duration of motor block were significantly higher in groups II and III when compared to group I. However, the difference in duration of analgesia, Ramsay sedation scores, bradycardia, and hypotension was statistically insignificant between the groups.
Conclusion:
Intravenous dexmedetomidine in doses of 0.75 and 1 mcg/kg significantly prolongs the two-dermatome regression time and duration of the motor block when compared to 0.5 mcg/kg dose. Hence, it is better to titrate the dose between 0.75 and 1 mcg/kg, as the administration of bolus intravenous Dex in doses ranging between 0.75 and 1 mcg/kg appears to provide adequate intraoperative block characteristics while maintaining hemodynamic stability without any significant respiratory depression or other adverse effects.
More Related Videos
Related Concept Videos
Parenteral Anesthetics: Overview
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Stages of General Anesthesia
Depolarizing Blockers: Pharmocokinetics
Skeletal Muscle Relaxants: Adverse Effects
Unlike...

