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Effect of Boron on Sympathetic Skin Response in Rats
Gulbahar Boyuk1, Nazan Dolu2, Busra Aksoy3
1From the Department of Physiology, Faculty of Medicine, Ankara Medipol University, Ankara, Turkey.
Indian Journal of Dermatology
|February 19, 2024
Summary
Boron cream significantly increased sweat gland activity in rats, as measured by electrodermal activity (EDA). This suggests boron enhances sympathetic nerve activity, impacting skin conductivity.
Area of Science:
- Physiology
- Toxicology
- Dermatology
Background:
- Boron's reproductive and growth effects are well-documented in animal studies.
- Electrodermal activity (EDA) measures eccrine sweat gland function, influenced by sympathetic nervous system activity.
Purpose of the Study:
- To investigate the impact of boron cream on sweat gland activity.
- To assess changes in electrodermal activity (EDA) following topical boron application.
Main Methods:
- Rats were divided into four groups, receiving either EDA recording gel, thyme oil cream, 10% boron cream, or 30% boron cream.
- Creams were applied to the hind paw soles, and EDA, including skin conductivity levels (SCL), was recorded.
- Tonic (resting) and phasic (stimulated) SCL measurements were taken.
Main Results:
- The 30% boron cream group (Group 4) exhibited significantly higher tonic SCL compared to all other groups (P < 0.001).
- Phasic SCL measurements were also significantly elevated in the 30% boron cream group compared to all other groups (P < 0.05).
Conclusions:
- Boron application, particularly at a 30% concentration in cream, demonstrably increases sweat gland activity.
- These findings indicate that boron enhances sympathetic nerve activity, leading to increased electrodermal activity.
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