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[Relation between blood eosinophilia and allergic respiratory disease in 2 different school-age populations]
Insights
Environmental factors significantly impact children's respiratory health. Higher peripheral blood eosinophil counts correlate with increased allergic respiratory diseases, particularly in industrialized areas.
Area of Science:
- Environmental Health
- Pediatric Allergy
- Immunology
Background:
- Allergic respiratory diseases are a significant health concern in children.
- Environmental exposures, such as living in industrialized versus rural areas, may influence disease prevalence.
- Peripheral blood eosinophil levels are a known marker for allergic inflammation.
Purpose of the Study:
- To investigate the correlation between peripheral blood eosinophil percentages and allergic respiratory diseases in children.
- To compare disease prevalence and eosinophilia in children from industrialized and rural environments.
Main Methods:
- A comparative study involving two groups of children aged 6-14 years.
- Data collection included self-administered questionnaires and measurement of peripheral blood eosinophil percentages.
- Statistical analysis using the chi-square method was employed.
Main Results:
- Children in the industrialized area showed a higher prevalence of allergic respiratory diseases and higher eosinophilia rates (33% vs. 26%).
- Eosinophilia was significantly associated with recurrent rhinitis, relapsing bronchitis, asthmatic bronchitis, and positive skin tests to allergens.
- In the rural district, eosinophilia was also linked to male sex.
Conclusions:
- A strong association exists between increased peripheral blood eosinophils and respiratory diseases in children, especially in industrialized settings.
- Eosinophilia serves as a potential indicator for relapsing respiratory conditions and may be a prognostic factor in allergology.
- Elevated eosinophil counts could predict frequent bronchospasms in patients with asthmatic syndrome.
Abstract:
Two groups of children from 6 to 14 years old have been compared to explain correlation between haematic eosinophils and allergic respiratory diseases related with the environment where they live. First group was formed by 350 pupils of Sesto S. Giovanni, and industrialized town, the second group by 345 pupils of Cogliate, a country place. The screening was been preceded by a set of questions self-managed and it consisted in the determinations percentage of peripheral blood eosinophils. Patients whose eosinophils were more than 4% have been considered eosinophilia carrier. The results have been elaborated with statistical method "chi square". Results proved the greatest prevalence of allergic respiratory diseases in urban population with a greater eosinophilia spreading (33% in comparison with 26%; p less than 0.05). Eosinophilia appeared connected with recurrent rhinitis (p less than 0.001) relapsing bronchitis (p less than 0.001) relapsing bronchitis (p less than 0.001) asthmatic bronchitis (p less than 0.001) positive results of skin tests to 4 allergens (p less than 0.001) and in rural district also with male sex (p less than 0.05). In industrialized areas, in special way there is a closed relation between respiratory diseases and peripheral blood eosinophils increased. Eosinophilia will be find in relapsing respiratory pathology and it will apply to allergology controls. It could represent an unfavourable element of prognosis foresee the possibility that episodic bronchus-spasms will be frequent in patients with asthmatic syndrome.