m6A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Tribbles-related protein 3 (TRIB3) promotes lung adenocarcinoma (LUAD) growth by inhibiting the Hippo signaling pathway. This TRIB3 interaction with LATS1 offers a potential therapeutic target for YAP-driven lung cancer.
Area Of Science
- Oncology
- Molecular Biology
- Cell Signaling
Background
- Dysregulation of the Hippo/Yes-associated protein (YAP) pathway is linked to tumor progression and therapy resistance in lung adenocarcinoma (LUAD).
- Elevated Tribbles-related protein 3 (TRIB3) levels correlate with poor prognosis in some lung cancers.
Purpose Of The Study
- To investigate if increased TRIB3 enhances LUAD malignancy and progression via the Hippo signaling pathway.
- To elucidate the molecular mechanisms underlying TRIB3's role in LUAD.
Main Methods
- Correlation analysis of TRIB3 expression and LUAD progression.
- Assessment of TRIB3's effect on TEAD luciferase activity and Hippo pathway signaling.
- Investigation of TRIB3's interaction with large tumor suppressor kinase 1 (LATS1).
- Analysis of METTL3-mediated N6-methyladenosine modification of TRIB3.
Main Results
- A positive correlation was found between elevated TRIB3 expression and LUAD progression.
- TRIB3 enhances TEAD luciferase function, suppresses Hippo pathway activity, increases total YAP protein, and promotes YAP nuclear localization.
- TRIB3 directly interacts with LATS1, inhibiting Hippo signaling.
- Reduced METTL3-mediated modification of TRIB3 leads to increased TRIB3 expression in LUAD cells.
Conclusions
- TRIB3 promotes LUAD cell growth and invasion by interacting with LATS1 and inhibiting the Hippo signaling pathway.
- TRIB3 represents a potential biomarker for unfavorable prognosis in LUAD.
- TRIB3 may be a therapeutic target for YAP-driven lung cancer.
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