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Bacterial pseudaminic acid binding to Siglec-10 induces a macrophage interleukin-10 response and suppresses
I-Ming Lee1, Hsing-Yu Wu2, Takashi Angata2
1Department of Marine Biotechnology and Resources, National Sun Yat-sen University, No. 70 Lien-hai Road, Kaohsiung, 804201, Taiwan.
Abstract:
Pseudaminic acid (Pse) on pathogenic bacteria exopolysaccharide engages with the sialic acid-binding immunoglobulin-type lectin (Siglec)-10 receptor on macrophages via the critical 7-N-acetyl group. This binding stimulates macrophages to secrete interleukin 10 that suppresses phagocytosis against bacteria, but can be reverted by blocking Pse-Siglec-10 interaction with Pse-binding protein as a promising therapy.
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