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[Clinical study on the efficacy of a sustained-release theophylline-based preparation in infants with chronic asthma]

P Bertolani, G C Bernini, S Amarri

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |September 1, 1985
    PubMed

    Insights

    Sustained-release theophylline effectively managed recurrent bronchial asthma in infants. Most asthma episodes occurred when theophylline therapy was stopped, indicating its therapeutic value.

    Area of Science:

    • Pediatric Pulmonology
    • Pharmacology
    • Clinical Medicine

    Context:

    • Recurrent bronchial asthma poses a significant challenge in infants.
    • Theophylline is a bronchodilator used in asthma management.
    • Sustained-release formulations aim to improve therapeutic adherence and efficacy.

    Purpose:

    • To evaluate the efficacy of sustained-release theophylline in preventing recurrent bronchial asthma episodes in infants.
    • To monitor theophylline blood levels during treatment.

    Summary:

    • Nine infants (3-17 months) with recurrent bronchial asthma received sustained-release theophylline for 6 months.
    • Eight asthma episodes were observed in 7 infants; 7 episodes occurred during therapy suspension.
    • Theophylline blood levels were monitored, with over 70% falling within the normal therapeutic range (6-20 µg/ml).

    Impact:

    • Sustained-release theophylline appears effective in reducing bronchial asthma exacerbations in infants.
    • Maintaining consistent theophylline therapy is crucial for preventing asthma attacks.
    • This study supports the use of sustained-release theophylline for pediatric asthma management.

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