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Vitamin D levels and olfactory dysfunction in multiple sclerosis patients
Zidan Gao1, Zhuoma Danzhen2,3, Junyu Zhu2
1School of Clinical Medicine, Soochow University, Suzhou, China.
Objective:
The objective was to explore the possible relationship between the serum vitamin D level and olfactory impairment in a population of multiple sclerosis (MS) patients in Guizhou, China.
Methods:
We included 25 patients with MS and 18 healthy controls (HCs) who were recruited from the Affiliated Hospital of Guizhou Medical University from February 2021 to September 2021. The University of Pennsylvania Smell Identification Test (UPSIT) was used to test the patients' sense of smell, and the level of serum 25-hydroxyethylene polyprotein D was measured.
Results:
Serum vitamin D levels and UPSIT scores were significantly different between the MS group and the control group (both p < 0.001). Moreover, a significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients (r = 0.537, p = 0.021).
Conclusions:
The serum vitamin D level may be involved in the regulation of olfactory dysfunction in MS patients in Guizhou, China.
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