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Related Experiment Video

Updated: May 7, 2026

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Magnesium Disorders: Core Curriculum 2024.

Emmanuel A Adomako1, Alan S L Yu1

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American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
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PubMed
Summary
This summary is machine-generated.

Magnesium is vital for human health, yet low magnesium (hypomagnesemia) is common and linked to chronic diseases like diabetes. This review covers magnesium disorders, pathophysiology, and new treatments for clinicians.

Keywords:
HypermagnesemiaTRPM6hypomagnesemiamagnesium supplementmagnesium transport

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Molecular Biology

Background:

  • Magnesium is essential for numerous molecular and catalytic processes in humans, including energy transfer and genome maintenance.
  • Despite its abundance, hypomagnesemia is prevalent and frequently undiagnosed, with links to chronic conditions such as diabetes mellitus.
  • Hypermagnesemia, though less common, can present dramatically, necessitating clinical awareness.

Purpose of the Study:

  • To review current knowledge on magnesium disorders, integrating advances in molecular biology and genetics.
  • To provide clinicians and trainees with a resource for managing common clinical scenarios involving magnesium imbalances.
  • To discuss evolving treatment approaches, including the repurposing of medications like sodium/glucose cotransporter 2 inhibitors.

Main Methods:

  • Literature review integrating recent advances in molecular biology and genetics of magnesium disorders.
  • Analysis of epidemiologic data linking magnesium levels to chronic diseases.
  • Discussion of current and emerging therapeutic strategies for magnesium dysregulation.

Main Results:

  • Hypomagnesemia is common, often undiagnosed, and associated with chronic diseases like diabetes mellitus.
  • Hypermagnesemia, while less frequent, can have severe clinical presentations.
  • Advances in understanding pathophysiology and new therapeutic options are transforming the management of magnesium disorders.

Conclusions:

  • Magnesium homeostasis is critical for human health, and disorders require greater clinical attention.
  • Understanding the genetic basis and molecular pathophysiology aids in diagnosing and managing magnesium imbalances.
  • Novel therapeutic strategies, including repurposed medications, offer promising new avenues for treating magnesium disorders.