Related Experiment Video
Updated: Jul 2, 2025
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
34.5K
Th2 cells in rapid immune responses and protective avoidance reactions
1Research Department, Geriatric Research Center, University of California Medical Center, San Francisco, San Francisco, California, USA.
Summary
Type 2 helper cells (Th2 cells) drive allergic reactions and immune responses. Therapies targeting Th2 cell cytokines, like anti-IL-5 and anti-IL-4/IL-13, are effective for conditions such as asthma and atopic dermatitis.
Area of Science:
- Immunology
- Allergy Research
- Cellular Immunology
Background:
- Type 2 helper T cells (Th2 cells) are crucial for immune responses.
- Th2 cells produce cytokines like IL-4, IL-5, and IL-13.
- These cytokines mediate allergic reactions and host defense against parasites and toxins.
Purpose of the Study:
- To outline the role of Th2 cells in immune responses.
- To highlight the involvement of Th2 cytokines in allergic diseases.
- To discuss the therapeutic implications of targeting Th2 pathways.
Main Methods:
- Review of Th2 cell differentiation and function.
- Analysis of Th2 cytokine contributions to specific immune responses.
- Examination of clinical data for anti-cytokine therapies.
Main Results:
- Th2 cells orchestrate IgE class-switching and allergic reactions.
- Th2 cytokines (IL-4, IL-5, IL-13) drive eosinophilia, mucus production, and epithelial changes.
- Anti-cytokine monoclonal antibodies show success in treating asthma and atopic dermatitis.
Conclusions:
- Th2 cell-mediated pathways are central to allergic diseases.
- Targeting Th2 cell-derived cytokines offers effective therapeutic strategies.
- Monoclonal antibody treatments provide significant benefits for specific patient groups.
Related Concept Videos
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
01:40Cell-mediated Immune Responses
68.3K
Overview
68.3K
01:23Cells of the Adaptive Immune Response
986
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
986
01:20Special Features of Adaptive Immunity
819
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
819
01:24B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
01:22T Cell Activation and Clonal Selection
732
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
732