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Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

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Real-Time Tissue Classification Using a Novel Optical Needle Probe for Biopsy.

Lukasz Surazynski^1,2, Ville Hassinen¹, Miika T Nieminen^1,3

¹Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.

Applied Spectroscopy

|February 19, 2024

Summary

This study introduces a smart needle probe using diffuse optical spectroscopy for real-time tissue classification during core needle biopsies. The probe achieved nearly 80% accuracy in identifying rat organs, improving biopsy guidance.

Keywords:

Diffuse optical spectroscopy classification core needle biopsy smart probe

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Area of Science:

Biomedical Engineering
Optical Spectroscopy
Machine Learning

Background:

Core needle biopsy is crucial for cancer diagnosis, typically guided by ultrasound.
Ultrasound guidance requires significant user expertise and can be affected by patient movement and artifacts.
An optically enhanced probe could provide real-time tissue property information, aiding radiologists.

Purpose of the Study:

To develop and characterize a core needle biopsy probe enhanced with diffuse optical spectroscopy.
To evaluate the probe's ability for real-time tissue differentiation and organ identification.
To validate the probe's potential to inform interventional radiologists during biopsy procedures.

Main Methods:

A custom core needle probe integrated with diffuse optical spectroscopy was designed.
Optical spectra were collected from various rat tissues (blood, fat, heart, kidney, liver, lungs, muscle).
Machine learning classifiers (SVM, k-NN) were trained and evaluated using k-fold cross-validation for tissue classification.

Main Results:

The probe successfully collected optical spectra from diverse biological tissues.
Machine learning models demonstrated feasibility in differentiating tissue types based on optical signatures.
The best-performing model achieved nearly 80% accuracy in real-time automated classification of rat organs.

Conclusions:

The diffuse optical spectroscopy-enhanced needle probe shows promise for real-time tissue recognition.
This technology could enhance the precision and safety of core needle biopsies.
Further development may lead to improved interventional radiology guidance systems.