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Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
Published on: January 19, 2024
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[Association analysis between mixed exposure to phenols and semen quality]
Xiao-Li Shen1,2, Wei-Feng Tang1, Junxia Liu1
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Se Pu = Chinese Journal of Chromatography
|February 20, 2024
Summary
Environmental phenols, like parabens, may negatively impact male fertility. Exposure to mixed phenols, particularly ethyl paraben and methyl paraben, was linked to lower sperm concentration and total sperm count in young men.
Area of Science:
- Environmental Health
- Reproductive Toxicology
- Analytical Chemistry
Context:
- Endocrine-disrupting phenols (bisphenols, parabens, triclosan) are ubiquitous environmental contaminants.
- Previous studies on phenols and semen quality yielded inconsistent results, often examining single compounds.
- Limited research exists on the effects of mixed phenolic compound exposure on male reproductive health.
Purpose:
- To investigate the associations between individual and mixed exposure to 18 phenolic compounds and semen quality parameters.
- To evaluate the impact of environmental phenols on sperm concentration, motility, and morphology.
- To identify specific phenolic compounds contributing to adverse semen quality outcomes.
Summary:
- A study analyzed urine samples from 799 male volunteers for 18 phenolic compounds using HPLC-MS/MS.
- Semen quality was assessed using a computer-aided semen analyzer.
- Multiple linear regression and weighted quantile sum (WQS) models revealed negative associations between ethyl paraben (EtP) exposure and sperm concentration/total sperm count.
- Mixed phenol exposure, with methyl paraben (MeP) and EtP as key contributors, was significantly linked to decreased sperm concentration.
Impact:
- Phenol exposure, especially to parabens, may adversely affect semen quality in young males.
- Findings highlight the importance of considering mixed chemical exposures in environmental health research.
- Results contribute to understanding the risks of endocrine disruptors on male reproductive health.
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