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Updated: Jul 2, 2025
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Microbiome: Role in Inflammatory Skin Diseases
Xue-Er Zhang1, Pai Zheng1, Sheng-Zhen Ye1,2
1Chengdu University of Traditional Chinese Medicine, Chengdu, 6610075, People's Republic of China.
Journal of Inflammation Research
|February 20, 2024
Summary
Skin microbiota dysregulation contributes to inflammatory skin diseases (ISDs). Understanding these microbial shifts and immune responses is key to developing targeted microbiome therapies for conditions like psoriasis and atopic dermatitis.
Area of Science:
- Microbiology
- Immunology
- Dermatology
Background:
- The skin hosts a diverse microbiota essential for immunity and pathogen defense.
- Dysbiosis of the skin microbiome is linked to immune dysregulation and inflammatory skin diseases (ISDs).
Purpose of the Study:
- To review microbial alterations and immune dysregulation in common ISDs.
- To explore the role of skin microbiota in the pathogenesis of ISDs.
- To highlight potential microbiome-specific therapies for ISDs.
Main Methods:
- Literature review of studies on skin microbiota and inflammatory skin diseases.
- Analysis of microbial composition and function in conditions like psoriasis, rosacea, atopic dermatitis, seborrheic dermatitis, diaper dermatitis, and Malassezia folliculitis.
- Examination of immune responses triggered by microbial dysbiosis.
Main Results:
- Alterations in skin microbiota composition and function compromise the skin barrier, leading to water loss and abnormal lipid metabolism.
- Microbial toxins can degrade the stratum corneum, facilitating pathogen entry and systemic immune activation.
- Specific microbes like Malassezia can trigger immune cascades involving dendritic cells and Th17 cells, promoting inflammation.
Conclusions:
- The human skin microbiome plays a significant role in the development and progression of ISDs.
- Understanding the interplay between skin microbiota and the immune system offers new therapeutic avenues.
- Future research should focus on developing targeted therapies based on the skin microbiome's specific roles in ISDs.
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