Genetic Markers Associated with Postpartum Depression: A Review
Joshua Harry Chandra1, Candy Kurniawan1, Irma Melyani Puspitasari1,2
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Neuropsychiatric Disease and Treatment
|February 20, 2024
Summary
Postpartum depression (PPD) is linked to specific genetic variations. The serotonin transporter gene (5-HTTLPR) and oxytocin receptor gene (OXTR) show significant associations with PPD risk.
Area of Science:
- Reproductive Medicine
- Genetics
- Psychiatry
Background:
- Postpartum depression (PPD) significantly impacts maternal well-being and infant development.
- Biological and psychosocial factors contribute to PPD etiology.
- Understanding genetic influences is crucial for PPD management.
Purpose of the Study:
- To review current research on the association between genetic polymorphisms and PPD.
- To identify specific genes implicated in PPD susceptibility.
Main Methods:
- Systematic literature search of PubMed and Scopus databases.
- Keywords included "postpartum depression," "postnatal depression," "genetic," and "polymorphism."
- Inclusion criteria applied to 27 selected articles.
Main Results:
- The serotonin transporter gene (5-HTTLPR) polymorphism is strongly associated with PPD.
- Oxytocin receptor gene (OXTR) polymorphisms also show significant links to PPD.
- Several other genetic polymorphisms were investigated but showed less consistent associations.
Conclusions:
- Genetic factors, particularly variations in 5-HTTLPR and OXTR, play a role in PPD.
- Further research into PPD biomarkers is essential for improved diagnosis and treatment.
- Genetic insights may pave the way for personalized PPD interventions.
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